艾贝宁夜间睡眠应用

作者：管理员来源：新晨医药日期：2014/3/20 21:47:09 人气：

Title:Sleep quality of mechanically ventilated patients sedated with dexmedetomidine
Abstract
Purpose: Dexmedetom- idine is thought to activate an endogenous pathway that naturally promotes non-rapid eye movement (NREM) sleep. Dexmedetomidine may induce restorative sleep, that is, NREM stage 3 and 4 (slow wave sleep; SWS) or sleep continuity in mechanically ventilated patients. Few data have been published, however, on the sleep characteristics of mechanically ventilated patients dur- ing dexmedetomidine infusion.
Methods: We recorded polysom- nography (PSG) for 24 h in mechanically ventilated patients sedated with dexmedetomidine. Dex- medetomidine (0.2–0.7 lg/kg/h) was administered intravenously to main- tain the Richmond Agitation– Sedation Scale between -1 and -4 only during the nighttime (9:00 p.m. to 6:00 a.m.). During the daytime, we interrupted the sedatives and analge- sics unless the patient complained of discomfort. When this occurred midazolam or opioids were adminis- tered intermittently. Sleep stages and the frequency of arousal/awakening during the nighttime were analyzed using Rechtschaffen and Kales crite- ria. Results: For the ten mechanically ventilated adult patients recruited into the study, the median total sleep time (TST) during the night was 4.7 h (IQR, 4.2–8.1 h), and 78 % of sleep occurred during the night (median 78 %, IQR: 69–88 %). Sleep architecture was exclusively NREM sleep stage 1 (median 28.9 % of TST) and stage 2 (median 71.2 % of TST). Neither SWS (median 0 % of TST) nor rapid eye movement (REM) sleep (median 0 % of TST) was observed. Median frequency of arousals/awakenings was 9.3/h (IQR,3–19.5/h).
Conclusions: In mechanically ventilated patients, nighttime infusion of dexmedetomi- dine preserved the day-night cycle of sleep but induced severely disturbed sleep architecture without evidence of SWS or REM sleep.
Keywords Dexmedetomidine .Sleep stage . Mechanical ventilation .Sedation
下载PDF全文

本文网址：

上一篇：危重病人的识别与管理

下一篇：护理部、医教部联合参与重症医学科小儿ICU晨交班

已有条评论信息，点击查看网友评论

艾贝宁夜间睡眠应用

栏目分类

站内搜索

热门文章