右美托咪定用于无创通气的镇静效果的临床前研究

The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation A Preliminary Study

Noninvasive ventilation (NIV) is extremely effective for treatment of respiratory failure associated with acute cardiogenic pulmonary edema and exacerbation of chronic obstructive pulmonary disease.1–4 Its usefulness has also been suggested for other acute respiratory failures, such as in postoperative5 and immunocompromised patients.6 However, delirium and agitation cause serious complications,7,8 and even if indicated, NIV sometimes fails with these complications.9 In this study, we hypothesized that dexmedetomidine would be effective as a sedative during NIV, and investigated whether dexmedetomidine can be used without adversely affecting the respiratory state of patients on NIV.

PDF文档