艾贝宁用于非机械通气患者无呼吸抑制研究

Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care

Richard M Venn, John Hell and R Michael Grounds
St George’s Hospital, London, UK
Crit Care 2000, 4:302–308

The respiratory effects of dexmedetomidine were retrospectively examined in 33 postsurgical patients involved in a randomised, placebo-controlled  trial after extubation in the intensive care unit  (ICU). Morphine requirements were  reduced by  over 50%  in  patients receiving dexmedetomidine. There were no differences in respiratory rates, oxygen saturations, arterial pH and arterial partial carbon dioxide tension (PaCO2) between the groups. Interestingly the arterial partial oxygen tension (PaO2) : fractional inspired oxygen (FIO2) ratios were statistically significantly higher in the dexmedetomidine  group. Dexmedetomidine  provides important postsurgical analgesia and appears to  have no clinically important adverse effects on respiration in the surgical patient who requires intensive care.

Keywords:   2-Adrenoceptor agonist, analgesia, dexmedetomidine, intensive care, postoperative, respiratory, sedation

查看PDF全文

The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation: A Preliminary Study

Shinji Akada, MD, PhD
Shinhiro Takeda, MD, PhD
Yuko Yoshida, MD
Keiko Nakazato, MD
Masaki Mori, MD
Takashi Hongo, MD, PhD
Keiji Tanaka, MD, PhD
Atsuhiro Sakamoto, MD, PhD

BACKGROUND: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.
METHODS: This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.
RESULTS: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 ::: 0.94 and -1.23 ::: 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.
CONCLUSION: This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.
(Anesth Analg 2008;107:167–70)

查看PDF全文

Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient–ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea

Intensive Care Med (2013) 39:543–557

查看PDF全文